Chronic Cluster Headache

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Key Questions
  • What is cluster headache?
  • How are cluster headache and migraine differentiated?
  • For what other conditions is cluster headache often misdiagnosed?
  • How are episodic cluster headache and chronic cluster headache different?
  • What are cluster cycles?
  • What does timing of attacks reveal about the involvement of the hypothalamus in cluster headache and what implications does that have?
  • What associations exist between lifestyle factors — such as sleep and alcohol use — and cluster headache?
  • What health care provider should treat cluster headache?
  • What medications and therapies can be used acutely and preventively in cluster headache?
  • Can neuromodulation therapy be helpful in cluster headache management?
  • How are grassroots efforts exploring the use of psilocybin in cluster headache?
  • What research is in progress in cluster headache?
Interview Notes

Find more about Christopher Gottschalk, MD, FAHS and his work here:

Treatments Mentioned
  • Beta blockers
  • CGRP monoclonal antibodies
  • CGRP oral treatments
  • Depakote
  • Eptinezumab (Vyepti)
  • Lithium
  • Nasal sprays
  • Nerve blocks
  • Oxygen
  • Psilocybin
  • Steroids
  • Sumatriptan injections
  • Topamax
  • Vagal nerve stimulator (neuromodulation device)
  • Verapamil
  • Zolmitriptan nasal sprays

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

Christopher Gottschalk, MD, FAHS

Professor of Clinical Neurology; Director, Headache & Facial Pain Program
Yale Medicine

Christopher Gottschalk, MD, is the chief of the Yale School of Medicine Division of General Neurology, as well as an assistant professor of neurology. Dr. Gottschalk established the first headache medicine program at Yale, the Yale Headache and Facial Pain Center, where he continues to treat patients with chronic headaches and facial pain. In addition to his clinical work at Yale, Dr. Gottschalk is researching ways to optimize interventions to improve headache diagnosis and management across medical specialties. Recurring moderate to severe headaches are often misdiagnosed and poorly treated, which is a problem that Dr. Gottschalk would like to change.

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Miles for Migraine is a registered 501(c)(3) nonprofit organization with the mission of improving the lives of people with migraine and other headache disorders, and their families, by raising public awareness about this disease, and helping to find a cure. Miles for Migraine produces fun walk/run events, typically a 2-mile walk and 5K and 10K races to raise money for migraine research. We also host adult education days, and a youth program for kids and teens impacted by migraine and other headache disorders.

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